Lou Gehrig (left) and Babe Ruth (right) at League Park in 1927. The legendary Babe Ruth (at right in photo from 1927) hit the most home runs of any visiting player at League Park including the 500th of his Major League Baseball career. Lou Gehrig (left) – "The Iron Horse" – hit the second most. To read more about the historic 500th home run, see this story from the 1929 Cleveland Plain Dealer. The life of Lou Gehrig is commemorated in this article on the official site of the NY Yankees.